PCSK9: From discovery to therapeutic applications

Biosynthesis of Silver nanoparticles from Actinomycetes for therapeutic applications

Silver is composed of a large percentage of silver oxide due to their large ratio of surface to bulk silver atoms. Silver nanoparticles have been a potent antibacterial, antifungal, anti-viral and anti-inflammatory agent. A simple, eco-friendly, inexpensive biosynthetic method was employed to synthesize silver nanoparticles.  The present study aimed at the comparative study of silver nanopartic...

Biosynthesis of Silver nanoparticles from Actinomycetes for therapeutic applications

Silver is composed of a large percentage of silver oxide due to their large ratio of surface to bulk silver atoms. Silver nanoparticles have been a potent antibacterial, antifungal, anti-viral and anti-inflammatory agent. A simple, eco-friendly, inexpensive biosynthetic method was employed to synthesize silver nanoparticles.  The present study aimed at the comparative study of silver nanopartic...

Apoptosis: from Signalling Pathways to Therapeutic Tools

Apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. It is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal DNA fragmentation. Although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...

Integrin αIIbβ3: from discovery to efficacious therapeutic target.

From the initial description of platelets in 1882, their propensity to aggregate and to contribute to thrombosis was apparent. Indeed, excessive platelet aggregation is associated with myocardial infarction and other thrombotic diseases whereas Glanzmann thrombasthenia, in which platelet aggregation is reduced, is a bleeding syndrome. Over the last half of the 20th century, many investigators h...

Optical Elastography: From Theory to Clinical Applications